How much PENNSAID® can I use each day?

Always follow your doctor’s instructions on how to use PENNSAID. The recommended dose is 40 drops per affected knee, 4 times a day. If you have osteoarthritis (OA) of the knee in both knees, this would be 40 drops, 4 times a day on each knee. Do not use more than the recommended dose.

Each bottle of PENNSAID contains enough solution to treat 1 knee for an entire month. If you have OA in both knees, ask your doctor for 2 bottles of PENNSAID.

If I’m overweight, do I need to apply more than 40 drops, 4 times a day?

No. The PENNSAID daily dose is not based on weight. Simply apply PENNSAID at the recommended dose: 40 drops per affected knee, 4 times a day.

If I only have pain in the front of my knee, do I still have to put PENNSAID on all 4 sides of my knee?

Always apply PENNSAID to all 4 sides of the knee(s). Since OA of the knee affects the entire knee, applying PENNSAID to just the top of the knee could lessen the relief you experience.

Can PENNSAID be used on other joints?

PENNSAID is indicated for the signs and symptoms of OA of the knee(s) and has not been studied in other joints. Always follow your doctor’s instructions on how to use PENNSAID.

How long does it take for PENNSAID to dry?

Drying times may vary. Your knee should be dry to the touch within a relatively short period of time.

How long should I wait after applying PENNSAID to apply a heat compress?

Do not use heating pads or apply bandages to the treated knee(s). Heat is often used to loosen stiffened joints. However, when heat is combined with PENNSAID, it could change how PENNSAID is absorbed.

Will lotions or other medications be pulled through my skin when I apply PENNSAID?

In clinical trials, there were no reports of poisons or other chemicals being absorbed after use of PENNSAID. Just to be sure, always wash your hands before and after each application of PENNSAID. Your knee should be clean and dry before you apply PENNSAID.

What other pain relief products can I use with PENNSAID?

When taking PENNSAID, avoid using any other nonsteroidal anti-inflammatory drugs, or NSAIDs. Some examples of NSAIDs are ibuprofen and naproxen. Talk to your doctor about what other medicines you can take while using PENNSAID.

Can I still use PENNSAID if I take warfarin (Coumadin®)?

The use of PENNSAID with warfarin has not been studied. Tell your doctor about all of the medications, prescription or over the counter, that you are taking. Only your doctor can decide if PENNSAID is right for you.

For any other questions, please contact Product Monitoring at 1-800-778-7898.

INDICATION
PENNSAID® is a nonsteroidal anti-inflammatory drug (NSAID) used for treating the signs and symptoms of osteoarthritis of the knee(s).

IMPORTANT RISK INFORMATION

WARNING: CARDIOVASCULAR (CV) AND GASTROINTESTINAL (GI) RISK

Nonsteroidal anti-inflammatory drugs (NSAIDs) may increase the risk of serious blood clots in the heart, or cause a heart attack or stroke. These risks can cause death. The risk may increase the longer NSAIDs are used. Patients who have heart disease or are at risk for heart disease may be at greater risk
Do not use PENNSAID in patients who are in the hospital for heart bypass surgery grafts

NSAIDs cause an increased risk of serious stomach problems or problems in the intestines. Patients could bleed or develop a hole in their stomach or intestines. All of these problems can cause death. These problems can happen at any time with no warning when using NSAIDs. Older patients are at greater risk for these problems

Tell your doctor if you have:
• High blood pressure, heart failure, or had any heart surgeries
• A history of ulcers or bleeding in the stomach or intestines
• Kidney or liver problems

The most common side effects of PENNSAID occur where it is put on the skin such as dry skin (32%), red and firm skin rash, skin rash with blisters, and itching. Other common side effects include: upset stomach, stomach pain, gas, diarrhea, and nausea.

Serious reactions can occur even if you never used PENNSAID before. NSAIDs can cause bad skin reactions that can be fatal.

A rise in liver tests can occur with NSAID therapy. Stop PENNSAID if this occurs and does not go away or if it gets worse.

Using NSAIDs for a long time can hurt the kidneys. Use PENNSAID carefully in the elderly, those with damaged kidneys, bad hearts, bad livers, and those taking water pills or ACE inhibitors. Do not take other NSAIDS unless your physician says it is OK.

Do not use PENNSAID if you are pregnant or breast-feeding. Do not use PENNSAID on children.

Avoid exposing treated knee to the sun or tanning lamps. Wash and dry hands before and after use. Avoid contact of PENNSAID with the eyes, the mouth and the nose. Do not apply to open wounds. Do not apply heat or binding items to the treated knee.

You are encouraged to report negative side effects of prescription drugs to the Food and Drug Administration (FDA). Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

For more important risk information about PENNSAID, please read the PENNSAID Medication Guide and Full Prescribing Information and discuss any questions you have with your doctor.

COVIDIEN, COVIDIEN with logo and Covidien logo are U.S. and internationally registered trademarks of Covidien AG.
PENNSAID is a registered trademark of Nuvo Research Inc. Other brands are trademarks of their respective owners. © 2011 Covidien